ty -jour a2-梅斯托里诺，诺拉·阿鲁 - 马克斯，马克尔·G·乔（Marcel G. au） - 马克（Marques）。-2020 AB -Nalbuphine是一种激动剂 - 抗抗原剂阿片类药物，具有足够的镇痛特性，对呼吸系统的抑郁作用很少。但是，尚无有关狗Nalbuphine心血管效应的详细报告。这项研究的目的是评估Nalbuphine的连续速率输注（CRI）对健康的七氟硫富集犬的左心室收缩和舒张功能的影响。使用了1-4岁的18个混合式母狗，体重为9.9±3.8 kg。将狗随机分配到两组之一：纳尔布丁（g_n，，，， n = 9) and control (G_C，，，， n = 9). Anesthesia was induced and maintained with sevoflurane (2V%) followed by an intravenous (IV) bolus of nalbuphine (0.3 mg/kg) or 0.9% NaCl at equal volume and then CRI of nalbuphine (0.4 mg/kg/h) or 0.9% NaCl at an equal infusion rate. Echocardiographic and hemodynamic variables were determined at baseline and 20, 40, 60, and 80 minutes following start of CRI. No differences were found between groups for left ventricular systolic and diastolic variables obtained through conventional echocardiography and two-dimensional speckle tracking. Likewise, hemodynamic variables did not differ between groups. The E′/A′ ratio significantly increased at 20 minutes compared to baseline only in GN. Nalbuphine given at a CRI does not influence left ventricular systolic and diastolic function in healthy sevoflurane-anesthetized dogs. SN - 2090-8113 UR - https://doi.org/10.1155/2020/9278751 DO - 10.1155/2020/9278751 JF - Veterinary Medicine International PB - Hindawi KW - ER -