TY - JOUR A2 - Nandi, Sumanta AU - Klein, Robert AU - Nagy, oscar AU - Tóthová, cilla AU - Chovanová,Frederika PY - 2020 DA - 2020/06/15 TI -临床和乳酸脱氢酶及其同功酶在动物的诊断意义SP - 5346483六世- 2020 AB -乳酸脱氢酶(LDH)是广泛分布的酶在细胞各种生命系统,参与碳水化合物代谢催化乳酸和互变现象丙酮酸与NAD+/ NADH辅酶系统。组织细胞是乳酸脱氢酶同工酶的直接来源,这些同工酶自然分布在动物和人的血浆/血清中,产生特征剖面。这依赖于所有组织中的细胞内同工酶浓度,这些同工酶作为细胞自然降解的结果,对血浆/血清中的乳酸脱氢酶共同库有贡献。LDH广泛分布于体内,在心脏、肝脏、骨骼肌、肾脏和红细胞中活性较高,而在肺、平滑肌和大脑中活性较低。由于其广泛的活动在许多身体组织,乳酸脱氢酶在各种疾病中升高。有很多条件会增加LDH的活性。总乳酸脱氢酶升高是一个相当非特异性的发现。因此,当分离成同工酶组分时,LDH测定具有更大的临床意义。LDH活性及其血清、组织形态和组成在不同种属间存在较大差异。这些差异不允许从一个物种到另一个物种使用LDH同工酶的催化活性。 Instead, the pattern of serum LDH isoenzymes should be interpreted in respect to its species origin that is important in particular in veterinary medicine. Determination of total LDH activity and its isoenzyme pattern in serum of mammals had become one of the biochemical indicators in the assessment of organ disorders. When the content of cells is released from tissue to plasma, as on cell injury, the LDH isoenzyme pattern of the serum changes in favour of the profile of the affected organ (tissue) that can be used in the diagnostic practice. SN - 2090-8113 UR - https://doi.org/10.1155/2020/5346483 DO - 10.1155/2020/5346483 JF - Veterinary Medicine International PB - Hindawi KW - ER -