TY - JOUR TI - 的R18与聚精氨酸肽是有效得多的TAT-NR2B9c的（NA-1）肽当永久性大脑中动脉闭塞的大鼠VL之后给药60分钟 - 2016 PY - 2016 DA - 2016年5月10日DO- 10.1155/2016/2372710 UR - https://doi.org/10.1155/2016/2372710 AB - We examined the dose responsiveness of polyarginine R18 (100, 300, and 1000 nmol/kg) when administered 60 minutes after permanent middle cerebral artery occlusion (MCAO). The TAT-NR2B9c peptide, which is known to be neuroprotective in rodent and nonhuman primate stroke models, served as a positive control. At 24 hours after MCAO, there was reduced total infarct volume in R18 treated animals at all doses, but this reduction only reached statistical significance at doses of 100 and 1000 nmol/kg. The TAT-NR2B9c peptide reduced infarct volume at doses of 300 and 1000 nmol/kg, but not to a statistically significant extent, while the 100 nmol/kg dose was ineffective. The reduction in infarct volume with R18 and TAT-NR2B9c peptide treatments was mirrored by improvements in one or more functional outcomes (namely, neurological score, adhesive tape removal, and rota-rod), but not to a statistically significant extent. These findings further confirm the neuroprotective properties of polyarginine peptides and for R18 extend its therapeutic time window and dose range, as well as demonstrating its greater efficacy compared to TAT-NR2B9c in a severe stroke model. The superior neuroprotective efficacy of R18 over TAT-NR2B9c highlights the potential of this polyarginine peptide as a lead candidate for studies in human stroke. JF - Stroke Research and Treatment SN - 2090-8105 PB - Hindawi Publishing Corporation SP - 2372710 KW - A2 - Liebeskind, David S. AU - Milani, D. AU - Knuckey, N. W. AU - Anderton, R. S. AU - Cross, J. L. AU - Meloni, B. P. ER -