TY - JOUR A2 - Han, Hyung Soo AU - Shintani, Yasushi AU - Terao, Yasuko AU - Ohta, Hiroyuki PY - 2011 DA - 2010/12/01 TI - Molecular Mechanisms Underlying Hypothermia-Induced Neuroprotection SP - 809874 VL - 2011 AB - Stroke is a dynamic event in the brain involving heterogeneous cells. There is now compelling clinical evidence that prolonged, moderate cerebral hypothermia initiated within a few hours after severe ischemia can reduce subsequent neuronal death and improve behavioral recovery. The neuroprotective role of hypothermia is also well established in experimental animals. However, the mechanism of hypothermic neuroprotection remains unclear, although, presumably involves the ability of hypothermia to suppress a broad range of injurious factors. In this paper, we addressed this issue by utilizing comprehensive gene and protein expression analyses of ischemic rat brains. To predict precise target molecules, we took advantage of the therapeutic time window and duration of hypothermia necessary to exert neuroprotective effects. We proposed that hypothermia contributes to protect neuroinflammation, and identified candidate molecules such as MIP-3 α和Hsp70,值得进一步研究targets for therapeutic drugs acting as “hypothermia-like neuroprotectants.” SN - 2090-8105 UR - https://doi.org/10.4061/2011/809874 DO - 10.4061/2011/809874 JF - Stroke Research and Treatment PB - SAGE-Hindawi Access to Research KW - ER -