TY - JOUR A2 - 沃格尔，W. A2 - 浅井，A. AU - 瑞里，D. AU - Salh，B. PY - 2011 DA - 2012年11月6日TI - 营养品的设计：姜黄素的临床应用结肠炎症和癌症SP - 757890 VL - 2012 AB - 毫无疑问，天然食品添加剂姜黄素，从许多亚洲菜肴中使用的五颜六色的香料姜黄衍生，具有生物活性的多样化。在疾病从阿尔茨海默病到囊性纤维化范围从它的抗炎，抗肿瘤和代谢性能的改进，令人吃惊的角色。其上生长因子受体，信号转导分子和转录因子的影响，与它的后生效应一起被广泛认为是非凡。These pleiotropic attributes, coupled with its safety even when used orally at well over 10 g/day, are unparalleled amongst pharmacological agents. However, there is one drawback; apart from the luminal gastrointestinal tract where its pharmacology predicts that reasonable drug levels can be attained, its broader use is hampered by its poor solubility and hence near undetectable plasma levels. Medicinal chemistry and nanotechnology have resulted in the generation of compounds where the modified drug or its delivery system has improved matters such that this shortcoming has been addressed to some extent, with the surprising finding that it remains safe to use. It is predicted that either the parental compound or its derivatives may eventually find a place in the therapeutic management protocols of several conditions. SN - null UR - https://doi.org/10.6064/2012/757890 DO - 10.6064/2012/757890 JF - Scientifica PB - Hindawi Publishing Corporation KW - ER -