TY - JUR A2 - Chatterjee,Sumanta Au - Voelker,Johannes Au - Engert,Jonas Au - Voelker,Christine Au - BieNiussa,Linda Au - Schendzielorz,Philipp Au - Hagen,Rudolf Au - Rak,Kristen Py - 2021 DA - 2021 /04/07 Ti - 产后大鼠耳蜗核核亚核中的不同神经源性潜力 - 8871308 VL-2021 AB - 患有听力损失的患者,减少或不存在神经输入诱导耳蜗细胞核(CN)的形态变化。最近在该第一听觉继电器中鉴定了神经干细胞。传入神经信号及其对内在神经茎和祖细胞的影响已经在CN内的早期产后细胞的存活时撞击。这种听觉脑干核由三种不同的亚核:蛛丝耳蜗核(AVCN),后腔耳蜗核(PVCN)和背部耳蜗核(DCN)组成。由于这些细分均在蓬松和生理学差异,因此问题出现了神经源性利基中存在区域差异。从产后第九一天的CN被显微静脉释放到它们的亚核中并以自由浮细胞培养物和全部安装器官培养物培养。除细胞量化外,还进行对繁殖细胞和器官制剂的免疫细胞学和免疫组织学研究。PVCN部分显示出最高的有丝分歧势,而AVCN和DCN具有可比性。在所有三个隔室中检测到特异性干细胞标记物和分化为神经谱系细胞的能力。 The present study shows that in all subnuclei of rat CN, there is a postnatal neural stem cell niche, which, however, differs significantly in its potential. The results can be explained by the origin from different regions in the rhombic lip, the species, and the various analysis techniques applied. In conclusion, the presented results provide further insight into the neurogenic potential of the CN, which may prove beneficial for the development of new regenerative strategies for hearing loss. SN - 1687-966X UR - https://doi.org/10.1155/2021/8871308 DO - 10.1155/2021/8871308 JF - Stem Cells International PB - Hindawi KW - ER -