AU - Zhu AU - Yu, Lu- ying AU - Yu, Li-Ming AU - Zhang, Wei- hua AU - Deng, Jia-Jia AU - Liu, Shang-Feng AU - Huang, Wei- Zhang, Meng-Han AU - Lu, Yan-Qin AU -Han, xinxin AU - Liu，TI - Aging Induced p53/p21 in geniogossus Muscle Stem Cells and Enhanced Upper Airway Injury SP - 8412598 VL - 2020 AB -老龄化带来了相关的社会问题，如随着年龄的增加，肌肉萎缩和再生障碍等。肌肉的修复和再生依赖于肌肉干细胞(MuSCs)。阻塞性睡眠呼吸暂停(OSA)在老年人口中增加。阻塞性睡眠呼吸暂停会导致缺氧和上呼吸道肌肉损伤。然而，人们对年龄增长和缺氧对上气道肌肉的影响知之甚少。颏舌肌(GG)是维持上呼吸道开放的主要扩张肌。本文报道，随着年龄的增长，GG的肌纤维和MuSC功能下降，年龄的增长也减少了GG MuSC的迁移和增殖。p53和p21在肌肉组织和GG MuSCs中均有高表达。我们进一步发现，缺氧抑制了GG MuSC的增殖，降低了肌源性分化。 Then, hypoxia enhanced the inhibition effect of aging to proliferation and differentiation. Finally, we investigated that hypoxia and aging interact to form a vicious circle with upregulation of p53 and p21. This vicious hypoxia plus aging damage accelerated upper airway muscle injury. Aging and hypoxia are the major damage elements in OSA patients, and we propose that the damage mechanism of hypoxia and aging in GG MuSCs will help to improve upper airway muscle regeneration. SN - 1687-966X UR - https://doi.org/10.1155/2020/8412598 DO - 10.1155/2020/8412598 JF - Stem Cells International PB - Hindawi KW - ER -