TY - JOUR A2 - 西尼斯卡尔科,达里奥AU - 泛洪AU - 榄坪瑾AU - 塘,见W. AU - 梁,凯文K. AU - 赵明福,安东尼Y. AU - 吴,恩德斯K. PY - 2020DA - 2020年2月12日TI - 间充质干与组织融合技术相结合,使细胞在猪的肠吻合术SP促进伤口愈合 - 5142797 VL - 2020 AB -
目的。为了评价与吻合组织融合技术相结合的同种异体间充质干细胞(MSC)的可能生物效应。
方法。Sixteen pigs were divided into a 7 d group and 14 d group, each of which was further subdivided into an MSC-treated group and a control group. Five anastomoses per animal were established using LigaSure ForceTriad (Covidien, MA, USA), a tissue sealing system. Cell migration and tissue-specific differentiation potency, in addition to potential cytokine and genetic changes, were investigated.
结果。有术后并发症没有显著组间差异吻合爆破压力。增殖细胞核抗原的数目(PCNA-)阳性细胞的MSC治疗组中是显著更高,因为与对照组相比(
P
=
0.021
)。标记细胞在粘膜层,绒毛,和固有层中发现,以及在椎板粘膜肌层,其中它们显示平滑肌细胞的特性。
结论。嫁接的MSCs显著促进上皮细胞和结缔组织细胞增殖和维持其细胞迁移能力和分化潜能的融合吻合组织,而不会造成严重的术后并发症。SN - 1687-966X UR - https://doi.org/10.1155/2020/5142797 DO - 10.1155 /五百一十四万二千七百九十七分之二千〇二十〇JF - 干细胞国际PB - Hindawi出版KW - ER -