TY - JOUR A2 - Widera, Darius AU - Wang，哲AU - Wei，全伟AU - Wang，郝AU - Han，林晓AU - Dai，洪剑AU - Qian，肖鑫AU - Yu，洪亮AU - Yin, Manqun AU - Shi, Fangxiong AU - Qi，Nianmin PY - 2020 DA - 2020/07/04 TI -使用人类脐带间充质干细胞治疗大鼠模型的Autoimmune-Induced卵巢功能早衰SP - 3249495六世- 2020 AB -卵巢功能早衰(POF)是女性不孕的主要原因之一,虽然它的原因是复杂多样的,可能与自身免疫缺陷有关。人脐带间充质干细胞(UCMSCs)可用于组织再生和修复。因此，本研究旨在确定UCMSCs在免疫因子诱导的大鼠POF中的作用。本研究将不同浓度的UCMSCs注射到POF大鼠体内。通过观察发情周期、卵泡形态、激素分泌、颗粒细胞增殖和凋亡情况来检测卵巢功能。结果表明，UCMSCs移植后，大鼠的发情周期恢复正常，卵泡发育明显改善。此外，治疗后血清中17-雌二醇(E2)、孕酮(P4)和anti-Müllerian激素(AMH)的浓度显著升高。UCMSCs移植也能减少颗粒细胞的凋亡，促进颗粒细胞的增殖。 All of these improvements were dose dependent. Furthermore, the results of related gene expression showed that transplanted human UCMSCs upregulated the expression of Bcl-2, AMH, and FSHR in the ovary of POF rats and downregulated the expression of caspase-3. These results further validated the potential mechanisms of promoting the release of cell growth factors and enhancing tissue regeneration and provide a theoretical basis for the clinical application of stem cells in the treatment of premature ovarian failure. SN - 1687-966X UR - https://doi.org/10.1155/2020/3249495 DO - 10.1155/2020/3249495 JF - Stem Cells International PB - Hindawi KW - ER -