TY - Jour Au - Bertoni，LéliaAu - Branly，Thomas Au - Jacquet，Sandrine Au - Desancé，MélanieAu - Desquilbet，Loïc互惠族 - Rivory，Pascaline Au - Hartmann，Daniel-Jean Au - Denoix，Jean-Marie Au - Audigié，Fabrice Au - Galéra，Philippe Au - Demoor，Magali Py - 2019 Da - 2019/05/02 Ti - 关节内注射2种不同剂量的自体和同种异体骨髓和脐带衍生的间充质干细胞触发变量Fetlock接头的炎症反应12声音实验马SP - 9431894 VL - 2019年AB - 骨关节炎是人类和马匹疼痛的重要且昂贵的原因。马已经被鉴定为人骨关节炎的合适模型。具有同种异体间充质干细胞（MSCs）的再生治疗是一个有前途的处理，但该程序的安全性继续讨论。本研究的目的是通过比较两种不同的剂量和两种不同的组织源，即骨髓和脐血，在同一个体的安慰剂治疗中评估同种异体MSC的关节内注射对同种异体MSC的关节内注射对健康关节的安全性。我们还评估了对骨髓衍生MSC治疗的自体对同种异体细胞的影响。在其4个脚锁接头中进行了12个临床声马。施用不同的MSC型中的每一个，剩余的胎块用磷酸盐缓冲盐水作为对照。六匹马每张关节获得1000万个细胞，6其他马匹每张关节接受了2000万个细胞。 Clinical and ultrasound monitoring revealed that allogeneic bone marrow-derived MSCs induced significantly more synovial effusion compared to umbilical cord blood-derived MSCs but no significant difference was noted within the synovial fluid parameters. The administration of 10 million cells in horses triggered significantly more inflammatory signs than the administration of 20 million cells. Mesenchymal stem cell injections induced mild to moderate local inflammatory signs compared to the placebo, with individual variability in the sensitivity to the same line of MSCs. Understanding the behavior of stem cells when injected alone is a step towards the safer use of new strategies in stem cell therapy, where the use of either MSC secretome or MSCs combined with biomaterials could enhance their viability and metabolic activity. SN - 1687-966X UR - https://doi.org/10.1155/2019/9431894 DO - 10.1155/2019/9431894 JF - Stem Cells International PB - Hindawi KW - ER -