TY - JOUR A2 - 桑切斯 - 吉霍，费尔明AU - 苏莺莺AU - 顾益盟 - 吴，罗瑞卿AU - 王，豪PY - 2018 DA - 2018年8月2日TI - 骨形态发生蛋白6和抑制免疫调节属性of BMMSCs via Id1 in Sjögren’s Syndrome SP - 9837035 VL - 2018 AB - Mesenchymal stem cells (MSCs) treatment has emerged as a promising approach for treating Sjögren’s syndrome (SS). Impaired immunoregulatory activities of bone marrow mesenchymal stem cells (BMMSCs) are found in both SS patients and animal models, and the underlying mechanism is poorly understood. Increased expression of BMP6 is reported to be related to SS. The aim herein was to determine the effects of BMP6 on BMMSCs function. BMMSCs were isolated from SS patients and NOD mice and showed a high level of BMP6 expression. The effects of BMP6 on BMMSCs function were investigated using 体外的BMMSCs分化 体外和 体内T细胞增殖和偏振测定。BMP6增加的BMMSCs的成骨细胞分化和抑制的BMMSCs的免疫调节性质。BMP6增强的T细胞增殖及Th1 / Th17细胞分化的T细胞共培养BMMSC系统。机械地，BMP6下调PGE2和通过Id1的（的DNA结合蛋白1抑制剂）上调的IFN-γ。中和BMP6和ID1的击倒可以恢复的BMMSCs免疫功能都 体外和 体内。本结果表明Id1的在BMP-介导的MSCs功能的新的作用，这可能有助于更好地理解MSC的作用在治疗自身免疫性疾病的机制。SN - 1687-966X UR - https://doi.org/10.1155/2018/9837035 DO - 10.1155 /九百八十三万七千○三十五分之二千○一十八JF - 干细胞国际PB - Hindawi出版KW - ER -