TY - JOUR A2 - Choi, Jane Ru AU - Fitzsimmons, Ross E. B. AU - Mazurek, Matthew S. AU - Soos, Agnes AU - Simmons, Craig A. PY - 2018 DA - 2018/08/19 TI - Mesenchymal Stromal/Stem Cells in Regenerative Medicine and Tissue Engineering SP - 8031718 VL - 2018 AB - As a result of over five decades of investigation, mesenchymal stromal/stem cells (MSCs) have emerged as a versatile and frequently utilized cell source in the fields of regenerative medicine and tissue engineering. In this review, we summarize the history of MSC research from the initial discovery of their multipotency to the more recent recognition of their perivascular identity 体内及其非凡的免疫调节和血管生成信号传导能力。同样，我们讨论了有关其发展起源的长期问题及其对一系列细胞谱系的差异化的能力。我们还突出了涉及其孤立，前体内扩张和临床用途的重要考虑因素和潜在风险。总体而言，本综述旨在担任研究的广度概述，这些研究已经证明了MSCs在各种临床环境中的效用，并继续解开这些细胞发挥治疗效果的机制。SN - 1687-966X UR - https://doi.org/10.1155/2018/8031718 Do - 10.1155 / 2018/8031718 JF - 干细胞国际PB - Hindawi KW - ER -