TY - JOUR A2 - 科尔，杰拉德A. AU - 穆尼奥斯 - 克里亚，伊格纳西奥AU - Meseguer酒店-里波列斯，何塞AU - Mellado洛佩斯，的Maravillas AU - Alastrue，阿古，安娜AU - Griffeth，理查德ĴAU - Forteza维拉，赫罗尼莫AU - CUGAT，拉蒙AU - 加西亚，蒙特塞拉特AU - 莫雷诺 - 曼萨诺，维多利亚PY - 2017年DA - 2017年7月9日TI - 人类髌上脂肪垫间充质干细胞诱导软骨和软骨修复重度骨性关节炎模型SP - 4758930 VL - 2017 AB - 软骨变性与退行性骨在严重的骨关​​节炎（OA）联合处理相关联。自发软骨再生极其有限。通常情况下，治疗包括部分或全部关节植入物。脂肪来源干细胞（ASC）移植已经显示出恢复软骨退化;然而，ASC的再生差异将取决于脂肪组织的来源。围绕膝盖的基础设施和髌上脂肪垫提供ASC的完全替代联合后的患者潜在的自体来源。当infrapatellar-和髌上衍生的基质血管级分（SVF）进行比较，一个显著更高CD105（+）人口在髌脂肪被发现。此外，髌SVF显示出增加的集落形成单位数和相比髌下馏分中培养较高群体倍增。 Both the suprapatellar- and infrapatellar-derived ASC were differentiated in vitro into mature adipocytes, osteocytes, and chondrocytes. However, the suprapatellar-derived ASC showed higher osteogenic and chondrogenic efficiency. Suprapatellar-derived ASC transplantation in a severe OA mouse model significantly diminished the OA-associated knee inflammation and cartilage degenerative grade, significantly increasing the production of glycosaminoglycan and inducing endogenous chondrogenesis in comparison with the control group. Overall, suprapatellar-derived ASC offer a potential autologous regenerative treatment for patients with multiple degenerative OA. SN - 1687-966X UR - https://doi.org/10.1155/2017/4758930 DO - 10.1155/2017/4758930 JF - Stem Cells International PB - Hindawi KW - ER -