TY - JOUR A2 - Rouabhia马哈茂德AU - 福吉埃尔-Sayed的判断，Karim M. AU - Dörfer，克里斯托夫E. PY - 2016 DA - 2016年5月29日TI - 间充质龈干/祖细胞：独特的组织工程宝石SP- 7154327 VL - 2016 AB - 人牙龈，其特征在于，其突出的无瘢痕愈合性质，是一个独特的组织和牙周装置的枢转部件，投资及在牙槽骨牙齿周围在各自的插槽。在过去的几年间充质牙龈干/祖细胞（G-MSC的），具有有前途的再生和免疫调节性质，已经被分离，并从牙龈固有层表征。这些细胞中，相对于其他的间充质干细胞/祖细胞的来源，丰富，容易获得，并且经由微创细胞分离技术容易地获得。The present review summarizes the current scientific evidence on G-MSCs’ isolation, their characterization, the investigated subpopulations, the generated induced pluripotent stem cells- (iPSC-) like G-MSCs, their regenerative properties, and current approaches for G-MSCs’ delivery. The review further demonstrates their immunomodulatory properties, the transplantation preconditioning attempts via multiple biomolecules to enhance their attributes, and the experimental therapeutic applications conducted to treat multiple diseases in experimental animal models in vivo. G-MSCs show remarkable tissue reparative/regenerative potential, noteworthy immunomodulatory properties, and primary experimental therapeutic applications of G-MSCs are very promising, pointing at future biologically based therapeutic techniques, being potentially superior to conventional clinical treatment modalities. SN - 1687-966X UR - https://doi.org/10.1155/2016/7154327 DO - 10.1155/2016/7154327 JF - Stem Cells International PB - Hindawi Publishing Corporation KW - ER -