TY - JOUR A2 - Pochampally，拉迪卡AU - 万宝至，哟AU - Houlihan的，Diarmaid D. AU - 赤泽，千寻AU - 冈野英之AU - 松崎，由美PY - 2013 DA - 2013年5月20日TI - 的前瞻性隔离507301 VL - - 2013 AB - 基于表面标记SP鼠和人骨髓间充质干细胞的间充质干细胞（MSC）当前正在定义为经历持续多能基质干细胞 体外生长，并且可以产生多种间充质谱系，例如脂肪细胞，软骨细胞，和成骨细胞的细胞。The regenerative and immunosuppressive properties of MSCs have led to numerous clinical trials exploring their utility for the treatment of a variety of diseases (e.g., acute graft-versus-host disease, Crohn’s disease, multiple sclerosis, osteoarthritis, and cardiovascular diseases including heart failure and myocardial infarction). On the other hand, conventionally cultured MSCs reflect heterogeneous populations that often contain contaminating cells due to the significant variability in isolation methods and the lack of specific MSC markers. This review article focuses on recent developments in the MSC research field, with a special emphasis on the identification of novel surface markers for the 体内本地化和小鼠和人类干细胞的潜在隔离。此外，我们还讨论了MSC亚型的生理意义 体内具体参照数据支持他们的HSC利基动态平衡的贡献。使用选择性标记（PDGFR的组合MSC的隔离 α和的Sca-1）是解决有关这些细胞中许多悬而未决的问题至关重要，必须极大地提高他们的治疗潜力的潜力。SN - 1687-966X UR - https://doi.org/10.1155/2013/507301 DO - 10.1155 /五十○万七千三百零一分之二千零十三JF - 干细胞国际PB - Hindawi出版公司公司KW - ER -