TY -的A2 Jurecic罗兰AU -奥尼尔,海伦C. AU - Griffiths, Kristin L. AU - Periasamy, Pravin AU - Hinton, Rebecca A. AU - Hey, Ying-Ying AU - Petvises, Sawang AU - Tan, Jonathan K. H. PY - 2011 DA - 2011/11/15 TI - Spleen as a Site for Hematopoiesis of a Distinct Antigen Presenting Cell Type SP - 954275 VL - 2011 AB - While spleen and other secondary tissue sites contribute to hematopoiesis, the nature of cells produced and the environment under which this happens are not fully defined. Evidence is reviewed here for hematopoiesis occurring in the spleen microenvironment leading to the production of tissue-specific antigen presenting cells. The novel dendritic-like cell identified in spleen is phenotypically and functionally distinct from other described antigen presenting cells. In order to identify these cells as distinct, it has been necessary to show that their lineage origin and progenitors differ from that of other known dendritic and myeloid cell types. The spleen therefore represents a distinct microenvironment for hematopoiesis of a novel myeloid cell arising from self-renewing hematopoietic stem cells (HSC) or progenitors endogenous to spleen. SN - 1687-966X UR - https://doi.org/10.4061/2011/954275 DO - 10.4061/2011/954275 JF - Stem Cells International PB - SAGE-Hindawi Access to Research KW - ER -