TY -的A2 Chilvers埃德温AU - Archontogeorgis, Kostas AU - Steiropoulos, Paschalis AU - Tzouvelekis, Argyris AU - Nena, Evangelia AU - Bouros, Demosthenes PY - 2012 DA - 2012/07/29 TI - Lung Cancer and Interstitial Lung Diseases: A Systematic Review SP - 315918 VL - 2012 AB - Interstitial lung diseases (ILDs) represent a heterogeneous group of more than two hundred diseases of either known or unknown etiology with different pathogenesis and prognosis. Lung cancer, which is the major cause of cancer death in the developed countries, is mainly attributed to cigarette smoking and exposure to inhaled carcinogens. Different studies suggest a link between ILDs and lung cancer, through different pathogenetic mechanisms, such as inflammation, coagulation, dysregulated apoptosis, focal hypoxia, activation, and accumulation of myofibroblasts as well as extracellular matrix accumulation. This paper reviews current evidence on the association between lung cancer and interstitial lung diseases such as idiopathic pulmonary fibrosis, sarcoidosis, systemic sclerosis, dermatomyositis/polymyositis, rheumatoid arthritis, systemic lupus erythematosus, and pneumoconiosis. SN - 2090-1836 UR - https://doi.org/10.1155/2012/315918 DO - 10.1155/2012/315918 JF - Pulmonary Medicine PB - Hindawi Publishing Corporation KW - ER -