TY - Jour A2 - 博迪斯-Woller，Ivan Au - Kurlawala，Zimple Au - Shownen，Paul H. Au - McMillan，Joseph D. Au - Beverly，Levi J Au - Friedland，Robert P. Py - 2021 Da - 2021/04/02 TI - Progression of Nonmotor Symptoms in Parkinson’s Disease by Sex and Motor Laterality SP - 8898887 VL - 2021 AB - Nonmotor symptoms (NMS) in Parkinson’s disease (PD) can start up to a decade before motor manifestations and strongly correlate with the quality of life. Understanding patterns of NMS can provide clues to the incipient site of PD pathology. Our goal was to systematically characterize the progression of NMS in PD ( N = 489), compared to healthy controls, HC ( N = 241), based on the sex of the subjects and laterality of motor symptom onset. Additionally, NMS experienced at the onset of PD were also compared to subjects with scans without dopaminergic deficit, SWEDD ( N = 81). The Parkinson’s Progression Markers Initiative (PPMI) database was utilized to analyze several NMS scales. NMS experienced by PD and SWEDD cohorts were significantly higher than HC and both sex and laterality influenced several NMS scales at the onset of motor symptoms. 性差异。与PD女性相比，Pd Males效果显着恶化了性，泌尿，睡眠和认知功能。PD女性报告的PD次数显着提高了疗效功能障碍和焦虑的心情超过7年，在PD发作后的前4年内具有显着的便秘。 横向差异。在发病时，具有右侧电动机优势的PD受试者报告了较高的自主功能障碍。随着帕金森的进步，左侧电机优势的受试者在展开中经历了显着的焦虑情绪。总之，男性在帕金森病中经历了NMS负担。除了焦虑的心情外，电机症状的外形没有显着影响NMS进展。我们在大型PD患者队列中分析了NMS，这些数据通过治疗减轻非等症状来改善PD患者的生活质量。SN - 2090-8083 UR - https://doi.org/10.1155/2021/8898887 Do - 10.1155 / 2021/8898887 JF - 帕金森病PB - Hindawi KW - ER -