TY - JOUR TI - 5-2-1 Criteria: A Simple Screening Tool for Identifying Advanced PD Patients Who Need an Optimization of Parkinson’s Treatment VL - 2020 PY - 2020 DA - 2020/03/24 DO - 10.1155/2020/7537924 UR - https://doi.org/10.1155/2020/7537924 AB -目的。5- (5 times oral levodopa tablet taken/day) 2- (2 hours of OFF time/day) 1- (1 hour/day of troublesome dyskinesia) criteria have been proposed by a Delphi expert consensus panel for diagnosing advanced Parkinson’s disease (PD). The aim of the present study is to compare quality of life (QoL) in PD patients with “5-2-1 positive criteria” vs QoL in PD patients without “5-2-1 positive criteria” (defined as meeting ≥1 of the criteria).方法。这是一个横截面，观察性，monocenter研究。三种不同的手段来评估生活质量：在39项生活问卷汇总指数得分为帕金森氏病种质量（PDQ-39SI）;主观等级感知生活质量（PQ-10）的;和EUROHIS-QOL 8项指标（EUROHIS-QOL8）。结果。From a cohort of 102 PD patients (65.4 ± 8.2 years old, 53.9% males; disease duration 4.7 ± 4.5 years), 20 (19.6%) presented positive 5-2-1 criteria: 6.9% for 5, 17.6% for 2, and 4.9% for 1. 37.5% (12/32) and 25% (5/20) of patients with motor complications and dyskinesia, respectively, presented 5-2-1 negative criteria. Both health-related (PDQ-39SI, 25.6 ± 14 vs 12.1 ± 9.2; ）and global QoL (PQ-10, 6.1 ± 2 vs 7.1 ± 1.3; ;EUROHIS-QOL8, 3.5 ± 0.5 vs 3.7 ± 0.4; ）是患者的5-2-1阳性的标准差。Moreover, nonmotor symptoms burden (Non-Motor Symptoms Scale total score, 64.8 ± 44.8 vs 39.4 ± 35.1; ）and autonomy for activities of daily living (ADLS scale, 73.5 ± 13.1 vs 89.2 ± 9.3; ）是患者的5-2-1阳性的标准差。Patient’s principal caregiver’s strain (Caregiver Stain Index, 4.3 ± 3 vs 1.5 ± 1.6; ）burden (Zarit Caregiver Burden Inventory, 28.4 ± 12.5 vs 10.9 ± 9.8; ）and mood (Beck Depression Inventory II, 12.2 ± 7.2 vs 6.2 ± 6.1; ）是患者的5-2-1阳性标准更糟，因为好。结论。生活质量是满足的5-2-1标准≥1的患者雪上加霜。本组病人及其照顾者更受整体。这些标准可以是用于识别患者，其中有必要优化帕金森氏治疗是有用的。JF - Parkinson’s Disease SN - 2090-8083 PB - Hindawi SP - 7537924 KW - A2 - Aasly, Jan AU - Santos-García, D. AU - de Deus Fonticoba, T. AU - Suárez Castro, E. AU - Aneiros Díaz, A. AU - McAfee, D. ER -