TY - JOUR TI - Long-Term Use of Antibiotics and Risk of Parkinson’s Disease in the Nurses’ Health Study VL - 2020 PY - 2020 DA - 2020/01/20 DO - 10.1155/2020/4038375 UR - https://doi.org/10.1155/2020/4038375 AB -目的。抗生素的使用是改变和多元化程度较低肠道微生物，其已与帕金森氏病最强的环境指标之一。据我们所知，没有事先研究审查长期使用抗生素和帕金森氏症之间的关联。设计。We conducted a prospective study of 59,637 women in the Nurses’ Health Study who reported total duration of antibiotic use at ages 20–39, 40–59, 60 +, or during the past 4 years. We used Cox Proportional Hazard regression to estimate hazard ratios and 95% confidence intervals for the association between categories of antibiotic use and risk of PD.结果。PD的一百八十例随访中得到了证实。Self-reported antibiotic use at ages 20–39, 40–59, and 60 +, as assessed in 2004, was not significantly associated with PD risk in our cohort. The hazard ratio comparing participants who used antibiotics for 2 or more months vs. 1–14 days at age 20–39 was 0.98 (95% CI: 0.54, 1.78), at age 40–59 was 1.44 (95% CI: 0.88, 2.33), and at age 60 +was 0.88 (95% CI: 0.53, 1.47). Antibiotic use during the past four years, as assessed in 2008, was also not associated with future risk of PD (HR: 1.14, 95% CI: 0.62, 2.10).结论。在这个队列研究中，我们没有观察到抗生素的使用和PD发病率之间的关联显著。我们研究的主要限制是曝光，这需要许多与会者回忆起他们的抗生素使用几十年，在过去的评估。因此，尽管这项研究的结果并不支持PD上的风险使用抗生素的效果，更大的调查依靠抗生素处方的记录将提供更确切的证据。JF - 帕金森病SN - 2090-8083 PB - Hindawi出版SP - 4038375 KW - A2 - Martella，Giuseppina AU - 帕拉西奥斯，纳塔利娅AU - 奥赖利，ÉilisĴAU - 施瓦兹，迈克尔A. AU - 阿西里奥，阿尔贝托ER -