TY - JOUR TI - Analysis of the Relationship between Type II Diabetes Mellitus and Parkinson’s Disease: A Systematic Review VL - 2019 PY - 2019 DA - 2019/11/23 DO - 10.1155/2019/4951379 UR - https://doi.org/10.1155/2019/4951379 AB - In the early sixties, a discussion started regarding the association between Parkinson’s disease (PD) and type II diabetes mellitus (T2DM). Today, this potential relationship is still a matter of debate. This review aims to analyze both diseases concerning causal relationships and treatments. A total of 104 articles were found, and studies on animal and “in vitro” models showed that T2DM causes neurological alterations that may be associated with PD, such as deregulation of the dopaminergic system, a decrease in the expression of peroxisome proliferator-activated receptor-gamma coactivator-1α（PGC-1α），在糖尿病富集增加磷蛋白的表达/磷富集在星形胶质细胞15（PED / PEA-15），和神经炎症，以及α-突触核蛋白淀粉样原纤维的形成的加速度。此外，临床研究描述了帕金森的症状有显着恶化的2型糖尿病发病后，七周失调的基因2型糖尿病和PD患者的DNA进行了鉴定。关于治疗，降糖药的作用，尤其是肠促胰岛素类似物制剂，似乎具有一定程度的神经保护作用，以PD患者。总之，对2型糖尿病和PD之间的相互作用的证据证明更强大的临床试验探索这种相互作用尤其是患者的这两个条件的临床管理。JF - 帕金森病SN - 2090-8083 PB - Hindawi出版SP - 4951379 KW - A2 - Teive，Helio公司AU - 卡马戈马卢夫，Fauze AU - 菲德，大卫AU - 阿尔维斯德Siqueira卡瓦略，阿尔兹拉ER -