TY -的TI -帕金森病在中亚和Transcaucasian国家:审查的流行病学、遗传学、临床特点,和获得保健六世- 2019 PY - 2019 DA - 2019/08/08做- 10.1155 / 2019/2905739 UR - https://doi.org/10.1155/2019/2905739 AB -我们对帕金森病(PD)的理解大大加速在过去的几年里,但主要进步发达,西方国家。对于中亚(CA)和外高加索(TC)国家的PD了解甚少。在此,我们通过检索MEDLINE、EMBASE、Scopus、Web of Science和谷歌Scholar数据库,回顾了CA和TC国家PD的临床特征、治疗方法、流行病学和遗传学。在获取PD care相关数据时,将搜索扩展到本地web资源。我们的调查结果显示,该地区的帕金森病患病率平均为每10万人62人。平均发病年龄女性为56.4±2.8岁,男性为63.3±3.5岁。目前缺乏关于该区域PD患病率的大规模国家研究。有限数量的遗传研究与小群和非结论性结果被确定。G2019S LRRK2突变是全世界最常见的PD突变,在153名乌兹别克患者中,5.7%的特发性PD患者和17.6%的家族性PD患者中发现了G2019S LRRK2突变。我们的综述强调了该地区PD卫生保健的系统性缺陷,包括缺乏专门研究PD的神经学家、PD诊断延迟、缺乏专门的PD护士和PD康复服务、获取PD药物和手术的机会有限以及PD输注治疗的缺乏。 Overall, this article demonstrated the paucity of data on this common neurological disorder in CA and TC countries and identified a number of healthcare areas that require an urgent consideration. We conclude that well-designed large-scale epidemiological, genetic, and clinical studies are desperately needed in this region. Healthcare professionals, local and national institutions, and stakeholders must come together to address deficiencies in PD healthcare systems in CA and TC countries. JF - Parkinson’s Disease SN - 2090-8083 PB - Hindawi SP - 2905739 KW - A2 - Teive, Hélio AU - Kaiyrzhanov, Rauan AU - Rizig, Mie AU - Aitkulova, Akbota AU - Zharkinbekova, Nazira AU - Shashkin, Chingiz AU - Kaishibayeva, Gulnaz AU - Karimova, Altynay AU - Khaibullin, Talgat AU - Sadykova, Dinara AU - Ganieva, Manizha AU - Rasulova, Khurshidakhon AU - Houlden, Henry ER -