TY - JOUR TI - The Parkinson’s Disease Composite Scale Is Adequately Responsive to Acute Levodopa Challenge VL - 2019 PY - 2019 DA - 2019/09/10 DO - 10.1155/2019/1412984 UR - https://doi.org/10.1155/2019/1412984 AB -背景。帕金森病综合量表（PDCS）是最近开发了易于使用的工具，使帕金森病（PD）相关症状的及时而全面的评估。虽然PDCS已经被广泛验证，其回应急性左旋多巴的挑战尚未证实。目的。探讨急性左旋多巴的挑战过程中运动障碍的电机检测元件协会主办的统一帕金森病评定量表（MDS-UPDRS）的变化和PDCS电机分数之间的相关性和计算上指示临床相关的改善PDC的截止区域。方法。A consecutive series of 100 patients with parkinsonism were assessed using the motor examination sections of the MDS-UPDRS and the PDCS at least 12 hours after the last levodopa dose and after the administration of a single dose of a suprathreshold immediate formulation of levodopa/benserazide reaching the “best ON.”结果秒。There was a high correlation between changes in the MDS-UPDRS and the PDCS motor scores (Spearman’s rho = 0.73, ）。受试者工作特征分析显示，在PDCS马达分数相当于14.6％-18.5％的改善到20-30％的改善在MDS-UPDRS运动检查。结论。该PDCS能够可靠和适当地急性左旋多巴挑战。在PDCS运动评分超过14.6-18.5％的阈值的任何改进可能代表左旋多巴临床相关响应。JF - 帕金森病SN - 2090-8083 PB - Hindawi出版SP - 1412984 KW - A2 - BODIS-Wollner酒店，伊万AU - 品特，大卫AU - 马丁内斯 - 马丁，巴勃罗AU - Janszky，AU的József - 科瓦奇，诺伯特ER -