TY - JOUR TI - Knowing Your Beans in Parkinson’s Disease: A Critical Assessment of Current Knowledge about Different Beans and Their Compounds in the Treatment of Parkinson’s Disease and in Animal Models VL - 2019 PY - 2019 DA - 2019/10/30 DO - 10.1155/2019/1349509 UR - https://doi.org/10.1155/2019/1349509 AB - This review contains a critical appraisal of current knowledge about the use of beans in both animal models and patients with Parkinson’s disease (PD). The potential beneficial effects of beans in PD are increasingly being touted, not only in scientific journals but also by the lay media. While there is a long tradition in Ayurvedic medicine of prescribing extracts from刺毛黧豆(MP),其种子含有5%L-3,4- dihydroxyphenylalanin(L-DOPA),许多其它豆类也含有L-DOPA(蚕豆,菜豆和大豆),或具有其它成分(咖啡和可可),该可能受益PD患者。事实上,豆衍生化合物可引起帕金森病的动物模型中的神经保护作用,而在人的PD患者的几项研究表明,电机性能豆提取物摄入后改善。但是,有几个参数对抗认为豆类作为PD一种自然疗法:(i)从动物PD模型的结果不一定直接适用于人类;(ⅱ)豆有许多生物活性成分,其中的一些可以在大剂量有害;(三)人PD患者的研究是单剂量或豆乳在很短的时间给药的效果稀少,仅报告;和(iv)对豆治疗的长期功效或副作用没有数据可用。因此,有关使用bean作为PD“自然”疗法持保留意见似乎是有道理的。JF - 帕金森病SN - 2090-8083 PB - Hindawi出版SP - 1349509 KW - A2 - Teive,Helio公司AU - Rijntjes,米歇尔ER -