TY - JOUR TI - 的Meta分析GBA2018 PY - - 2018 DA - 帕金森病VL - 相关临床症状的2018年9月27日做的 - 10.1155 /三百一十三万六千四百十五分之二千〇十八UR - https://doi.org/10.1155/2018/3136415 AB -背景。GBA基因已经被证明是一个关键基因PD的风险。大量研究已经对PD患者具有独特的临床特征讨论GBA运营商（GBA + PD). However, there was lack of updated comprehensive analysis on the topic. In order to clarify the association betweenGBA变种和PD的临床表型，我们进行这一综合荟萃分析。方法。MEDLINE，EMBASE和Cochrane被用于执行搜索。严格的选择标准，分别采取筛选新发表的文章或数据。应用Revman 5.3软件应用来执行的总的统计分析，并在软件漏斗图被用来评估该出版物偏见。结果。一共有26篇文章，其中包括931GBA + PD and 14861GBAPD的非携带者（GBA − PD) were involved in the final meta-analysis, and 14 of them were either newly added publications or related data newly analyzed compared with the version published in 2015. Then, a series of symptoms containing depression, orthostatic hypotension, motor fluctuation, wearing-off, and freezing were newly analyzed due to more articles eligible. Besides, clinical features like family history, AAO, UPDRS-III, H-Y, and dementia previously analyzed were updated with new data added. Significant statistical differences were found in wearing-off, family history, AAO, UPDRS-III, and dementia (OR: 1.14, 1.65; MD: −3.61, 2.17; OR: 2.44; ：0.03，<0.00001 <0.00001，0.003，和<0.00001）。抑郁症略有关联GBA + PD (OR: 1.47; ：0.04）。临床症状，如H-Y，体位性低血压，马达波动，和冷冻没有特征GBA + PD.结论。我们的研究结果表明，有独特的临床特征GBA + PD which can help the management of the whole duration of PD patients. JF - Parkinson’s Disease SN - 2090-8083 PB - Hindawi SP - 3136415 KW - A2 - Aasly, Jan AU - Zhang, Yuan AU - Shu, Li AU - Zhou, Xun AU - Pan, Hongxu AU - Xu, Qian AU - Guo, Jifeng AU - Tang, Beisha AU - Sun, Qiying ER -