TY -的A2 Lloret安娜盟——刘,李阳AU -白,小君非盟- Liu Fangxi盟——徐应盟,赵美盟——赵Chuansheng盟——周Zhike PY - 2022 DA - 2022/02/03 TI -肺癌通路Forkhead盒O1群(FOXO1)阿尔茨海默病的发病机制和亨廷顿氏舞蹈症SP - 7619255六世- 2022 AB -阿尔茨海默病(AD)和亨廷顿氏病(HD)是全球破坏性疾病。一直努力阐明这两种疾病的过程,然而,发病机理仍然是难以捉摸的,因为它涉及到多种因素的组合,包括遗传和环境因素的影响。探索forkhead盒子的潜在作用O1群(FOXO1)发展的广告和高清,我们确定了1853个差异表达基因(度)从19414年背景基因AD&HD /控制和FOXO1-low /高组。四个coexpression模块被加权预测基因coexpression网络分析(WGCNA),其中蓝色和绿松石模块与AD&HD最强的相关性和FOXO1的高表达。功能富集分析表明,在这些模块在吞噬体丰富度,cytokine-cytokine受体相互作用,细胞衰老,FOXO信号通路,神经退化的途径,gaba ergic突触,AGE-RAGE信号通路在糖尿病并发症。此外,FOXO1肺癌通路的广告和HD共同决定在全球监管网络,如FOXO信号通路、细胞衰老,AGE-RAGE信号通路在糖尿病并发症。基于绩效评估的曲线下的面积85.6%,FOXO1可以准确地预测广告和高清的发生。然后我们确定FOXO1肺癌通路的广告和高清,分别。更具体地说,FOXO1参与了FOXO信号通路和细胞衰老在广告;相应地,FOXO1参与胰岛素抵抗,胰岛素,FOXO高清信号通路。 Next, we use GSEA to validate the biological processes in AD&HD and FOXO1 expression. In GSEA analysis, regulation of protein maturation and regulation of protein processing were both enriched in the AD&HD and FOXO1-high groups, suggesting that FOXO1 may have implications in onset and progression of these two diseases through protein synthesis. Consequently, a high expression of FOXO1 is a potential pathogenic factor in both AD and HD involving mechanisms of the FOXO signaling pathway, AGE-RAGE signaling pathway in diabetic complications, and cellular senescence. Our findings provide a comprehensive perspective on the molecular function of FOXO1 in the pathogenesis of AD and HD. SN - 1942-0900 UR - https://doi.org/10.1155/2022/7619255 DO - 10.1155/2022/7619255 JF - Oxidative Medicine and Cellular Longevity PB - Hindawi KW - ER -