TY -的A2 -崔,荀盟——刘黄文吉盟,壮族Hsiao-Chi盟——周,雌性大熊猫AU -李,Yu-Hsuan盟——赵Yu-Jhe AU - Wang Yung-Li盟——赵Hui-Wen PY - 2022 DA - 2022/03/27 TI -香烟烟雾暴露增加Glucose-6-phosphate脱氢酶,自噬、纤维化和肾细胞的衰老在体外和在活的有机体内SP - 5696686六世- 2022 AB -香烟(CS)是一种慢性阻塞性肺疾病的危险因素。我们试图调查完全可能的CS对肾细胞的影响。我们发现人类的可行性肾近端小管上皮细胞系(HK-2细胞)与CS提取物(CSE)治疗后下降。特别是,CSE在低浓度没有变化的影响细胞凋亡和坏死的表达。此外,CSE HK-2细胞自噬,fibrosis-related蛋白增加。伴随老化蛋白质和senescence-associated分泌表型(SASP)与CSE HK-2细胞治疗后增加。此外,RNA序列和基因集富集分析数据显示,glucose-6-phosphate脱氢酶(G6PD)活性氧(ROS)通路负责改变CSE-treated HK-2细胞。CSE G6PD表达式及其活动增加。此外,在HK-2 G6PD活性增加衰老细胞的抑制作用。CSE-treated抑制自噬增强衰老的细胞。 In a mouse model of CS exposure, CS caused kidney damage, including tubular injury and glomerulosclerosis. CS increased fibrosis, autophagy, and G6PD expression in kidney tissue sections. In conclusion, CS induced G6PD expression, autophagy, fibrosis, and senescence in kidney cells. G6PD has a protective role in CS-induced nephrotoxicity. SN - 1942-0900 UR - https://doi.org/10.1155/2022/5696686 DO - 10.1155/2022/5696686 JF - Oxidative Medicine and Cellular Longevity PB - Hindawi KW - ER -