TY -的A2 Corte-Real曼非盟- Ma, Peng-Wei AU - Wang Wei-Long盟——陈,日本AU -元,郝AU - Lu, Pei-Heng AU -高,魏盟——丁薛瑞盟——Lun, Yu-Qiang盟——梁、瑞盟——他,Zu-Hong AU -杨,钱非盟- Lu, Lian-Jun PY - 2022 DA - 2022/12/07 TI -治疗Ferroptosis抑制剂Ferrostatin-1减弱噪音性听力丧失通过抑制Ferroptosis和凋亡SP - 3373828六世- 2022 AB -头发细胞死亡引起过多的活性氧(ROS)已被确定为噪音性听力丧失的主要发病机理(NIHL)。最近的研究表明,顺铂,neomycin-induced耳毒性可以缓解ferroptosis抑制剂。然而,对NIHL ferroptosis抑制剂是否有保护作用仍然是未知的。我们调查的保护作用ferroptosis抑制剂ferrostatin-1 (Fer-1) NIHL CBA / J小鼠体内的保护作用研究Fer-1对叔丁基氢过氧化物(TBHP)全身在耳蜗毛细胞损伤体外外植体和HEI-OC1细胞。我们观察到ROS过载和脂质过氧化反应,导致外毛细胞(OHC)凋亡和ferroptosis噪声暴露后的小鼠耳蜗。凋亡诱导因子的表达水平mitochondria-associated 2 (AIFM2)大幅增加后海拔噪声暴露后上游P53蛋白的表达。ferroptosis抑制剂Fer-1was演示后进入内耳的系统性管理。管理Fer-1显著减轻噪音性听觉阈值升高和降低ohc的损失,内毛细胞(包含IHC)带状突触和听觉神经纤维(曾帮工)由噪声引起的。从力学上看,Fer-1显著降低噪音,TBHP-induced毛细胞脂质过氧化和铁积累,减轻ferroptosis因而在耳蜗细胞。此外,Fer-1治疗TfR1的水平下降,P53, AIFM2。 These results suggest that Fer-1 exerted its protective effects by scavenging of ROS and inhibition of TfR1-mediated ferroptosis and P53-AIFM2 signaling pathway-mediated apoptosis. Our findings suggest that Fer-1 is a promising drug for treating NIHL because of its ability to inhibit noise-induced hair cell apoptosis and ferroptosis, opening new avenues for the treatment of NIHL. SN - 1942-0900 UR - https://doi.org/10.1155/2022/3373828 DO - 10.1155/2022/3373828 JF - Oxidative Medicine and Cellular Longevity PB - Hindawi KW - ER -