TY -的A2 -劳夫,阿布杜尔AU - Li Ganglei盟——你们昌盛盟,朱昱盟——张Tiesong盟——顾,小君非盟-潘,健胃AU -王,冯盟——吴盟——黄粉丝,开元盟——徐康丽AU -吴,小民沈盟——剑PY - 2022 DA - 2022/02/03 TI -氧化损伤在缺血性中风:关注NADPH氧化酶4 SP - 1148874六世- 2022 AB -缺血性中风是全球残疾和死亡的主要原因。因此,迫切需要探讨其病理生理机制和寻找新的治疗策略的成功治疗。氧化应激和缺血性中风的关系越来越欣赏和正在吸引大量的注意力。ROS作为氧化应激源。是线粒体代谢的副产品,但主要的功能性产品NADPH氧化酶类(NOX)家庭成员。烟酰胺腺嘌呤二核苷酸磷酸氧化酶4 (NOX4)是最密切相关的形成活性氧在缺血性中风。它的表达显著调节脑缺血后,成为一个有前途的目标治疗缺血性中风。等一些药物针对NOX4 scm - 198, Iso, G-Rb1,桦木酸,电针刺激,显示效果是缺血性中风的治疗。MTfp-NOX4 POC中风的治疗提供了新的见解。这些疗法的组合也为缺血性中风的治疗提供新方法。 In this review, we summarize the subcellular location, expression, and pathophysiological mechanisms of NOX4 in the occurrence and development of ischemic stroke. We also discuss the therapeutic strategies and related regulatory mechanisms for treating ischemic stroke. We further comment on the shortcomings of current NOX4-targeted therapy studies and the direction for improvement. SN - 1942-0900 UR - https://doi.org/10.1155/2022/1148874 DO - 10.1155/2022/1148874 JF - Oxidative Medicine and Cellular Longevity PB - Hindawi KW - ER -