泰江-的A2,叮盛盟- Du,由非盟-刘,广绘盟——赵Luosha盟——姚明,鲁伊PY - 2020 DA - 2020/11/20 TI -保护mir - 204对Doxorubicin-Induced心肌细胞损伤的影响通过HMGB1 SP - 8819771六世- 2020 AB -阿霉素的毒性(阿霉素)限制了其临床应用。不过,目前还没有有效的药物来防止DOX-induced心脏损伤。mir - 204是一个新发现的microrna与许多保护对心血管疾病的影响。然而,目前还没有做过任何研究的影响在DOX-induced mir - 204心脏损伤。我们的研究旨在调查mir - 204对DOX-induced心肌损伤的影响。adenoassociated病毒系统用于实现心脏过度mir - 204。两周后,小鼠腹腔注射阿霉素(15毫克/公斤)诱导心脏损伤。H9c2心肌细胞用于验证mir - 204体外的作用。我们的研究表明,mir - 204表达减少DOX-treated心。mir - 204超表达改善心脏功能和减轻心脏炎症、细胞凋亡和自噬通过强力霉素诱导。 In addition, our results showed that miR-204 prevented DOX-induced injury in cardiomyocytes by directly decreasing HMGB1 expression. Moreover, the overexpression of HMGB1 could offset the protective effects of miR-204 against DOX-induced cardiac injury. In summary, our study showed that miR-204 protected against DOX-induced cardiac injury via the inhibition of HMGB1, and increasing miR-204 expression may be a new treatment option for patients with DOX-induced cardiac injury. SN - 1942-0900 UR - https://doi.org/10.1155/2020/8819771 DO - 10.1155/2020/8819771 JF - Oxidative Medicine and Cellular Longevity PB - Hindawi KW - ER -