TY - JOUR A2 - Andrade, José P. AU - Frizon, Tiago E. A. AU - Cararo, José H. AU - Saba, Sumbal AU - Dal-Pont, Gustavo C. AU - Michels, Monique AU - Braga, Hugo C. AU - Pimentel, Tairine AU - Dal-Pizzol, Felipe AU - Valvassori, Samira S. AU - Rafique, Jamal PY - 2020 DA - 2020/05/28 TI - Synthesis of Novel Selenocyanates and Evaluation of Their Effect in Cultured Mouse Neurons Submitted to Oxidative Stress SP - 5417024 VL - 2020 AB - Herein, we report the synthesis of novel selenocyanates and assessment of their effect on the oxidative challenge elicited by hydrogen peroxide (H₂Ø₂）中培养的小鼠的神经元。第一， α亚甲基 β羟基酯制备为烯丙基溴化物的前体。涉及所生成的溴化物和硒氰酸钠的反应物进行，以产生所期望的selenocyanates（3A-F）。我们从7日龄小鼠神经元的下一个准备文化（ ñ = 36 ）。H₂Ø₂（10^-5 M) was added into the culture flasks as an oxidative stress inducer, alone or combined with one of each designed compounds. (PhSe)₂用作阳性对照。据进行脂质评估（硫代巴比妥酸反应性物质，4-羟基-2- “ -nonenal，8-异前列烷），DNA（8-羟基-2- “ 脱氧鸟苷）和蛋白质（羰基）修正参数。最后，过氧化氢酶和超氧化物歧化酶的活动也进行了评价。在化合物，3B，3D和3F表现出抗氧化活性的最显着的图案，类似于（PHSE）₂。这些新的芳香selenocyanates可看好在最复杂的受审 体外研究甚至在临床前的水平。SN - 1942-0900 UR - https://doi.org/10.1155/2020/5417024 DO - 10.1155 /五百四十一万七千○二十四分之二千○二十○JF - 氧化医学和细胞寿命PB - Hindawi出版KW - ER -