TY -的A2 -蒙蒂,西蒙娜m . AU - Ramos-Chavez洛杉矶盟——Roldan-Roldan g . AU - Garcia-Juarez b . AU - Gonzalez-Esquivel, d . AU - Perez de la Cruz, g . AU -皮内b . AU - Ramirez-Ortega, d . AU -加西亚穆尼奥斯,非盟Herrera -吉梅内斯,b . AU -里奥斯,c . AU - Gomez-Manzo s . AU - Marcial-Quino j . AU -桑切斯Chapul l . AU - Carrillo莫拉,p . AU - Perez de la Cruz, v . PY - 2018 DA - 2018/11/21 TI -低血清色氨酸水平作为全球认知能力的指标Nondemented 50岁以上女性SP - 8604718六世- 2018 AB -老化是一个生理下降的过程。老年人的数量越来越多世界各地;因此,认知障碍的发生率、痴呆、和其他疾病与老化增加有关。收敛的主要细胞因子老化过程中线粒体功能障碍,抗氧化损伤,炎症和免疫反应下降等等。在这种情况下,这些细胞的变化会影响犬尿氨酸通路(KP),色氨酸(Trp)分解代谢的主要途径。KP代谢产物参与了衰老和神经退行性疾病。虽然有代谢物的变化水平随着年龄的增长,在这个时候,没有研究,评估认知能力下降导致的分解代谢波动老化。本研究的目的是评估Trp分解代谢的变化之间的关系和认知障碍与年龄通过KP代谢物水平变化在50岁以上的女性。七十七年nondemented 50岁以上的女性与标准化研究认知筛选评价西班牙语(Neuropsi),贝克焦虑量表(BAI),和老年抑郁量表(GDS)。血清的,犬尿氨酸(Kyn)犬尿酸(KYNA)和3-hydroykynurenine (3-HK)及谷胱甘肽比例(谷胱甘肽(GSSG)测量。 Results showed a negative correlation between age and Trp levels and a positive correlation between age and KYNA/Trp and 3-HK/Trp ratios. The level of cognitive impairment showed a significant positive association with age and with kynurenine pathway activation and a significant negative correlation with Trp levels. The GSH/GSSG ratio correlated positively with Trp levels and negatively with Kyn/Trp and 3-HK/Trp ratios. The depression score correlated negatively with Trp and positively with the 3-HK/Trp ratio. We concluded that KP activation increases with age and it is strongly associated with the level of cognition performance in nondemented women over 50 years of age. SN - 1942-0900 UR - https://doi.org/10.1155/2018/8604718 DO - 10.1155/2018/8604718 JF - Oxidative Medicine and Cellular Longevity PB - Hindawi KW - ER -