TY -的A2马哈茂德·扎m . AU -肖Yunjun盟——夏,俊杰AU -吴,双非盟- Lv, Ziquan AU -黄,Suli盟——黄、海盐盟——苏Xuefen AU - Cheng金泉盟——柯Yuebin PY - 2018 DA - 2018/09/20 TI -姜黄素抑制急性血管炎症通过血红素的激活Oxygenase-1 SP - 3295807六世- 2018 AB -姜黄素有几个属性,如抗炎治疗效果。血红素oxygenase-1 (HO-1)已经显示有cytoprotective效应在某些病理条件。然而,HO-1的角色在姜黄素的抗炎作用是未知的。在这项研究中,我们调查是否姜黄素的抗炎作用在血管可能参与HO-1的激活。新西兰白兔喂养常规控制饮食或控制饮食加上0.3%的姜黄素(wt / wt)四个星期。引起的急性血管炎症的兔子把衣领左侧颈总动脉为24小时。HO-1抑制剂和核被用于调查的角色HO-1在成卷的血管姜黄素的抗炎效果。我们也探讨了HO-1体外curcumin-induced激活的机制。血清胆红素和血管、肝脏和脾脏HO-1 mRNA水平显著增加在curcumin-treated兔子。血管炎症显著降低curcumin-treated动物与控制。 Treatment of the rabbits with an inhibitor of HO or HO-1 siRNA to knock down the carotid artery HO-1 abolished the ability of curcumin to inhibit vascular inflammation. Treatment of cultured human artery endothelial cells with curcumin induced the HO-1 expression through the activation of nuclear factor-E2-related factor 2 (Nrf2) and an antioxidant responsive element via the p38 MAPK signalling pathway. In conclusion, curcumin inhibits vascular inflammation in vivo and in vitro through the activation of HO-1. SN - 1942-0900 UR - https://doi.org/10.1155/2018/3295807 DO - 10.1155/2018/3295807 JF - Oxidative Medicine and Cellular Longevity PB - Hindawi KW - ER -