TY -的A2 -维克多,维克多·m . AU - Mando Chiara AU -安内尔利盖亚玛利亚盟——Novielli Chiara AU - Panina-Bordignon Paola盟了,Maddalena盟——Mazzocco玛蒂娜Ilaria AU - Cetin,艾琳PY - 2018 DA - 2018/08/14 TI -肥胖和高血糖对胎盘的影响线粒体SP - 2378189六世- 2018 AB - lipotoxic胎盘的环境是在母亲的肥胖,增加炎症和氧化应激。这些变化可能会改变线粒体功能,与过量的活性氧的生产,在一个恶性循环导致胎盘功能障碍和不良妊娠结局。在这里,我们假设母亲孕前的体重指数(BMI)和血糖水平可以改变胎盘线粒体。我们测量的线粒体DNA (mtDNA、实时PCR)和形态(电镜)在47个单例妊娠胎盘选择性剖腹产。37女性normoglycemic: 21个正常体重的女性,NW,和十六个肥胖妇女,OB / GDM (−)。十个肥胖妇女妊娠期糖尿病,OB / GDM (+)。OB / GDM(−)提出mtDNA水平较高与NW,建议增加了线粒体生物起源normoglycemic肥胖组。这些线粒体显示相似的形态学西北。相反,在OB / GDM (+), mtDNA并不显著增加和西北。然而,线粒体形态异常,指示功能受损。 The metabolic response of the placenta to impairment in obese pregnancies can possibly vary depending on several parameters, resulting in opposite strains acting when insulin resistance of GDM occurs in the obese environment, characterized by inflammation and oxidative stress. Therefore, mitochondrial alterations represent a feature of obese pregnancies with changes in placental energetics that possibly can affect pregnancy outcomes. SN - 1942-0900 UR - https://doi.org/10.1155/2018/2378189 DO - 10.1155/2018/2378189 JF - Oxidative Medicine and Cellular Longevity PB - Hindawi KW - ER -