TY - A2的汉尼拔曾盟——徐,康盟,刘帮非盟- Fu Chenxing PY - 2018 DA - 2018/07/22 TI -色氨酸途径针对抗氧化能力在胎盘SP - 1054797六世- 2018 AB -胎盘在怀孕期间胎儿发育起着至关重要的作用。胎盘的功能障碍可以由氧化应激和可能导致胎儿发育异常。因此,防止氧化应激的胎盘出生的重要手段,确保积极的结果。研究表明,色氨酸及其代谢物可以有效地清洁自由基(包括活性氧和活性氯)。因此,色氨酸及其代谢物建议在胎盘作为有效的抗氧化剂。然而,这些抗氧化性能的机制在胎盘仍是未知的。在这次审查中,我们总结的抗氧化性能研究色氨酸,色氨酸代谢产物和代谢酶。两种预测机制色氨酸的抗氧化性能进行了讨论。(1)色氨酸能激活的磷酸化激活后p62 mTORC1;磷酸化p62然后解开Nrf2和Keap1之间的交互,并激活Nrf2进入核诱导抗氧化蛋白的表达,从而提高细胞的抗氧化作用。 (2) 3-Hydroxyanthranilic acid, a tryptophan kynurenine pathway metabolite, changes conformation of Keap1, inducing the dissociation of Nrf2 and Keap1, activating Nrf2 to enter the nucleus and induce expressions of antioxidant proteins (such as HO-1), thereby enhancing cellular antioxidant capacity. These mechanisms may enrich the theory of how to apply tryptophan as an antioxidant during pregnancy, providing technical support for its use in regulating the pregnancy’s redox status and enriching our understanding of amino acids’ nutritional value. SN - 1942-0900 UR - https://doi.org/10.1155/2018/1054797 DO - 10.1155/2018/1054797 JF - Oxidative Medicine and Cellular Longevity PB - Hindawi KW - ER -