TY - Jour A2 - Mostafalou，Sara Au - Rezvanfar，Mohammad Amin Au - Shojaei Saadi，Habib A. Au - Gooshe，Maziar Au - Abdolghaffari，Abdolghaffari，Abdolghaffari，Amir Hosein Au - Baeeri，Maryam Au - Abdollahi，Mohammad Py - 2014年/02/19 Ti - 卵巢衰老的表型在高腺癌诱导的多囊卵巢模型SP - 948951 VL - 2014 AB - 卵巢老化和多囊卵巢综合征之间的大多数特征中存在突出类似的症状，效果和共性（PCOS）。尽管氧化应激在PCOS和老化的发病机制中批准作用，但尚未调查PCO和老龄化之间的联系。In this study we investigated the possible exhibition of ovarian aging phenotype in murine model of PCO induced by daily oral administration of letrozole (1 mg/kg body weight) for 21 consecutive days in the female Wistar rats. Hyperandrogenization showed irregular cycles and histopathological characteristics of PCO which was associated with a significant increase in lipid peroxidation (LPO) and reactive oxygen species (ROS) and decrease in total antioxidant capacity (TAC) in serum and ovary. Moreover, serum testosterone, insulin and tumor necrosis factor-alpha (TNF- α.PCO大鼠与健康对照相比，PCO大鼠的水平和卵巢基质金属蛋白酶-2（MMP-2）增加，而雌二醇和孕酮减少。几乎所有这些发现都有趣地发现与（卵巢）衰老鉴定的特征表明大鼠中的高衰老诱导的PCO与卵巢衰老的表型相关。为了我们的知识，这是第一份报告，为PCO衰老的现象提供了证据。SN - 1942-0900 UR - https://doi.org/10.1155/2014/948951 Do - 10.1155/2014 / 948951 JF - 氧化医学和蜂窝长寿PB - Hindwi Publishing Corporation KW - ER -