TY - JOUR A2 - Pirola, Luciano AU - Kondrashov, Alexey AU - Vranková， Stanislava AU - Dovinová， Ima AU - Ševčík, Rudolf AU - Parohová， Jana AU - Barta, Andrej AU - Pecháňová， Olga AU - Kovacsová，玛丽亚PY - 2012 DA - 2012/06/05 TI -新Alibernet红酒提取物的影响一氧化氮和活性氧产量在自发性高血压大鼠SP - 806285六世- 2012 AB -我们旨在执行化学分析Alibernet红酒和不含酒精的Alibernet红酒提取物(AWE)和调查的影响of AWE on nitric oxide and reactive oxygen species production as well as blood pressure development in normotensive Wistar Kyoto (WKY) and spontaneously hypertensive rats (SHRs). Total antioxidant capacity together with total phenolic and selected mineral content was measured in wine and AWE. Young 6-week-old male WKY and SHR were treated with AWE (24,2 mg/kg/day) for 3 weeks. Total NOS and SOD activities, eNOS and SOD1 protein expressions, and superoxide production were determined in the tissues. Both antioxidant capacity and phenolic content were significantly higher in AWE compared to wine. The AWE increased NOS activity in the left ventricle, aorta, and kidney of SHR, while it did not change NOS activity in WKY rats. Similarly, increased SOD activity in the plasma and left ventricle was observed in SHR only. There were no changes in eNOS and SOD1 expressions. In conclusion, phenolics and minerals included in AWE may contribute directly to increased NOS and SOD activities of SHR. Nevertheless, 3 weeks of AWE treatment failed to affect blood pressure of SHR. SN - 1942-0900 UR - https://doi.org/10.1155/2012/806285 DO - 10.1155/2012/806285 JF - Oxidative Medicine and Cellular Longevity PB - Hindawi Publishing Corporation KW - ER -