TY - Jour A2 - 埃吉尼奥 - 迪维尼·奥尔吉奥·奥斯基 - 萨佩斯，纳迪亚奥 - Zella，Davide Au - Bracale，Renata Au - Intrieri，Mariano Au - Scapagnini，Giovanni Py - 2012 Da - 2012/05/28 Ti -Pleiotropic Protective Effects of Phytochemicals in Alzheimer's Disease SP - 386527 VL - 2012 AB - Alzheimer’s disease (AD) is a severe chronic neurodegenerative disorder of the brain characterised by progressive impairment in memory and cognition. In the past years an intense research has aimed at dissecting the molecular events of AD. However, there is not an exhaustive knowledge about AD pathogenesis and a limited number of therapeutic options are available to treat this neurodegenerative disease. Consequently, considering the heterogeneity of AD, therapeutic agents acting on multiple levels of the pathology are needed. Recent findings suggest that phytochemicals compounds with neuroprotective features may be an important resources in the discovery of drug candidates against AD. In this paper we will describe some polyphenols and we will discuss their potential role as neuroprotective agents. Specifically, curcumin, catechins, and resveratrol beyond their antioxidant activity are also involved in antiamyloidogenic and anti-inflammatory mechanisms. We will focus on specific molecular targets of these selected phytochemical compounds highlighting the correlations between their neuroprotective functions and their potential therapeutic value in AD. SN - 1942-0900 UR - https://doi.org/10.1155/2012/386527 DO - 10.1155/2012/386527 JF - Oxidative Medicine and Cellular Longevity PB - Hindawi Publishing Corporation KW - ER -