TY - JOUR A2 - Rameshwar，Pranela AU - Mahapatra，Santanu嘉盟 - Chakraborty的，Subhankari普拉萨德AU - 罗伊，Somenath PY - 2011 DA - 2012/01/06 TI - 免疫调节作用丁香罗勒和抗坏血酸对尼古丁诱导小鼠腹腔巨噬细胞体外SP - 734319 VL - 2011 AB - The aim of this present study was to evaluate the immune functions and immune responses in nicotine-induced (10 mM) macrophages and concurrently establish the immunomodulatory role of aqueous extract of 丁香罗勒（AE-OG）和抗坏血酸。在这项研究中，亚硝酸盐世代被巨噬细胞表型的一些功能进行了研究。在那旁边，释放Th1型细胞因子的（TNF- α，IL-12）和Th2细胞因子（IL-10，TGF- β）通过ELISA测定，并通过实时PCR分析这些细胞因子在mRNA水平的表达。AE-OG，剂量为10  μ克/毫升，显著降低了烟碱诱导的NO的产生和表达iNOSII。Similar kinds of response were observed with supplementation of ascorbic acid (0.01 mM). The administration of Ae-Og and ascorbic acid increased the decreased adherence, chemotaxis, phagocytosis, and intracellular killing of bacteria in nicotine-treated macrophages. Ae-Og and ascorbic acid were found to protect the murine peritoneal macrophages through downregulation of Th1 cytokines in nicotine-treated macrophages with concurrent activation of Th2 responses. These findings strongly enhanced our understanding of the molecular mechanism leading to nicotine-induced suppression of immune functions and provide additional rationale for application of anti-inflammatory therapeutic approaches by O. gratissimum和抗坏血酸对尼古丁毒性期间的不同炎性疾病的预防和治疗。SN - 1942-0900 UR - https://doi.org/10.1155/2011/734319 DO - 10.1155 /七十三万四千三百一十九分之二千○十一JF - 氧化医学和细胞寿命PB - Hindawi出版公司公司KW - ER -