TY - JOUR A2 - 森下，龙一AU - 罗伊，Souvik AU - Sannigrahi，Santanu AU - 马宗达，Subhabrota AU - 戈什，巴拉拉姆AU - 萨卡，Biswajit PY - 2011 DA - 2011/10/15 TI - 白藜芦醇抗氧化的调节作用状态，来抑制细胞因子的表达和细胞凋亡的限制四氯化碳诱导的大鼠肝损伤SP - 703676 VL - 2011 AB - 最近的研究表明白藜芦醇在许多动物模型，如缺血，类风湿性关节炎，人类癌症和糖尿病的化学预防作用。本研究旨在探讨大鼠肝损伤模型四氯化碳白藜芦醇的化学预防潜力。Male Wistar rats were treated with carbon tetrachloride (0.4 g/kg body weight) intraperitoneally daily for 8 weeks. Resveratrol (100 mg/kg, 200 mg/kg body weight) was given orally from first day until the last day of experiment. The investigation assesses the effect of resveratrol on morphological, oxidative status, histopathological, immunohistochemical, and apoptotic analysis in carbon tetrachloride-challenged liver tissue. The study indicated that the inflammatory cytokines TNF- α和IL-6是在实验性大鼠深刻地表达，而白藜芦醇降低TNF-α的免疫阳性 α和IL-6和恢复攻击肝组织的改变的建筑结构。白藜芦醇也能抑制氧化应激和细胞凋亡保护肝细胞。SN - 1942-0900 UR - https://doi.org/10.1155/2011/703676 DO - 10.1155 /七十○万三千六百七十六分之二千○十一JF - 氧化医学和细胞寿命PB - Hindawi出版公司公司KW - ER -