TY - Jour A2 - Vincenzo，Di Lazzaro Au - Heidari，Mohammad Hassan Au - Amini，Abdollah Au - Bahrami，Zohreh Au - Shahriari，Ali Au - MovaFag，Abolfazle Au - Heidari，Reihane Py - 2013 Da - 2013/11/28TI - Effect of Chronic Morphine Consumption on Synaptic Plasticity of Rat’s Hippocampus: A Transmission Electron Microscopy Study SP - 290414 VL - 2013 AB - It is well known that the synapses undergo some changes in the brain during the course of normal life and under certain pathological or experimental circumstances. One of the main goals of numerous researchers has been to find the reasons for these structural changes. In the present study, we investigated the effects of chronic morphine consumption on synaptic plasticity, postsynaptic density thickness, and synaptic curvatures of hippocampus CA1 area of rats. So for reaching these goals, 24 N- 雄性大鼠随机分为三组吗啡（ N = 8. ）， 安慰剂 （ N = 8. ）和控制（ N = 8. ）组。在吗啡群中，使用吗啡（0.1,0.2,0.3和0.4）mg / ml和安慰剂（蔗糖）组蔗糖（％0.3）的复合物21天。在药物治疗结束后，动物吞噬并灌注鞘内吞噬，最后考虑Ca1海马样品进行超微结构研究，然后通过SPSS分析所获得的数据并进行单向分析的方差分析。我们的数据表明每个NM的突触数字^3.与其他两组（安慰剂和对照）相比，在吗啡组中发生显着变化（ P. < 0.001 ）统计分析在突触后密度的厚度方面揭示了群体之间的显着差异（ P. < 0.001 ）突触曲率（ P. < 0.007 ）。似乎对大鼠的吗啡依赖在海马的超微结构变化中起主要作用。SN - 2090-1852 UR - https://doi.org/10.1155/2013/290414 do - 10.1155 / 2013/290414 JF - 神经内科国际PB - Hindawi Publishing CorporationKW - ER -