TY -的A2马伦Diano AU - Tan,引进非盟-王,中研非盟-唐易盟——田,阴PY - 2023 DA - 2023/03/28 TI -改变人类海马亚区在整个寿命:反思白质结构和功能连通性SP - 7948140六世- 2023 AB -在增长和老龄化,海马在记忆的作用取决于其相互作用相关的大脑区域。特别是,两个亚区,前海马体(aHipp)和后海马(pHipp),扮演不同的和关键的角色在内存中处理。然而,在结构和功能上与年龄相关的海马条件的变化还不清楚。在这里,我们调查了与年龄相关的结构和功能特点,106名参与者(7 - 85岁)在静息状态基于分数各向异性(FA)和功能连通性(FC) aHipp和pHipp寿命。足协和俱乐部之间的相关性也探索识别耦合。此外,韦氏缩写智力量表(WASI)被用来探索认知能力和海马的变化之间的关系。结果表明,有功能分离和集成aHipp pHipp,和功能连接的数量pHipp aHipp的寿命。与年龄相关的FC变化显示四个不同的趋势(u型/倒u型/线性向上/向下线性)。,40岁左右的转变的关键时期。然后,FA分析表明,所有年龄对海马结构的影响是非线性的,和白质的完整性pHipp高于aHipp。 In the functional-structural coupling, we found that the age-related FA of the right aHipp (aHipp.R) was negatively related to the FC. Finally, through the WASI, we found that the age-related FA of the left aHipp (aHipp.L) was positively correlated with verbal IQ (VERB) and vocabulary comprehension (VOCAB.T), the FA of aHipp.R was only positively correlated with VERB, and the FA of the left pHipp (pHipp.L) was only positively correlated with VOCAB.T. These FC and FA results supported that age-related normal memory changes were closely related to the hippocampus subregions. We also provided empirical evidence that memory ability was altered with the hippocampus, and its efficiency tended to decline after age 40. SN - 2090-5904 UR - https://doi.org/10.1155/2023/7948140 DO - 10.1155/2023/7948140 JF - Neural Plasticity PB - Hindawi KW - ER -