TY - Jour A2 - Baroncelli，Laura Au - He，Miao Au - 张，海南Au - 唐，镇 - 楚欧 - 高，舒光PY - 2021DA - 2021/05/17 - 诊断和治疗潜力神经退行性疾病的外泌体微小RORNA SP - 8884642 VL-2021 AB - 神经变性障碍（NDS）的特征在于神经元和功能的逐渐丧失，最终导致渐进式神经损伤。鉴于医疗保健系统的沉重负担，用于早期诊断和治疗治疗的高效且可靠的生物标志物，以逆转NDS的进展迫切需要。利用外泌体miRNA作为生物标志物或最近的神经疾病的靶向治疗，已经存在越来越令人兴趣。In this review, we overviewed the updated studies on exosomal miRNAs as biomarkers and potential therapeutic approaches in NDs, as well as their association with the pathophysiology of this group of disorders, especially Alzheimer’s disease (AD), Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS), and Huntington’s disease (HD). The exosomal miRNAs that are commonly dysregulated across different NDs or are commonly used as therapeutic candidates were also identified and summarized. In summary, the feasibility of exosomal miRNAs as biomarkers and potential targeted therapy for NDs has been verified. However, due to the limitations of existing studies and the discrepancies across different studies, high quality laboratory and clinical investigations are still required. SN - 2090-5904 UR - https://doi.org/10.1155/2021/8884642 DO - 10.1155/2021/8884642 JF - Neural Plasticity PB - Hindawi KW - ER -