TY - JOUR A2 - 陈，拥军AU - 李，宇杰AU - 江泾AU - 唐，奇声AU - 田慧灵AU - 王，顺AU - 王紫东AU - 刘昊AU - 杨，佳艺AU -Ren, Jingyu PY - 2020 DA - 2020/09/04 TI - Microglia TREM2: A Potential Role in the Mechanism of Action of Electroacupuncture in an Alzheimer’s Disease Animal Model SP - 8867547 VL - 2020 AB - Alzheimer’s disease (AD) is one of the most serious public health concerns facing the world. Its characteristic feature is neuroinflammation due to microglial activation. Electroacupuncture is one of the therapies employed to improve the condition of patients with AD, although its mechanism of action is still to be determined. Triggering receptor expressed on myeloid cells 2 (TREM2) is a microglia-specific receptor that is involved in regulating neuroinflammation in AD. In this study, we applied senescence-accelerated mouse-prone 8 mice as the AD animal model, used the Morris water maze, and applied hematoxylin and eosin staining, immunofluorescence double staining, and Western blotting, to explore the effects and potential mechanisms of action of electroacupuncture. In summary, this study suggested that electroacupuncture treatment could improve the learning and memory abilities ( p < 0.05 ）和保护神经元。这些效果从针刺导致可上调在海马（TREM2表达 p < 0.01 ），这是用于在AD动物模型中的抗炎作用是必不可少的。然而，需要进一步的研究以结论性地表明在AD电的作用机制。SN - 2090-5904 UR - https://doi.org/10.1155/2020/8867547 DO - 10.1155 /八百八十六万七千五百四十七分之二千○二十〇JF - 神经可塑性PB - Hindawi出版KW - ER -