Ty-Jour A2 - 杨，景文艾 - 李，龙互惠·李·李，乐张，嘉新奥 - 黄，盛坝 - 刘，魏林·奥 - 王，志福·梁，胜祥芳涛，荆AU - Chen, Lidian PY - 2020 DA - 2020/08/28 TI - Disease Stage-Associated Alterations in Learning and Memory through the Electroacupuncture Modulation of the Cortical Microglial M1/M2 Polarization in Mice with Alzheimer’s Disease SP - 8836173 VL - 2020 AB - Microglia are the primary cells that exert immune function in the central nervous system, and accumulating evidence suggests that microglia act as critical players in the initiation of neurodegenerative disorders, such as Alzheimer’s disease (AD). Microglia seemingly demonstrate two contradictory phenotypes in response to different microenvironmental cues, the M1 phenotype and the M2 phenotype, which are detrimental and beneficial to pathogenesis, respectively. Inhibiting the M1 phenotype with simultaneous promoting the M2 phenotype has been suggested as a potential therapeutic approach for cure AD. In this study, we demonstrated that electroacupuncture at the Shenting and Baihui acupoints for 16 weeks could improve learning and memory in the Morris water maze test and reduce amyloid β- 蛋白质在Paretal Assabity Cortex和Entorhinal Cortex中的小鼠，温和和中度广告。此外，在追求的电机和Baihui穴位的电针不仅抑制了M1标记（Inos / IL-1 β）表达，但也增加了这些区域中的M2标记（CD206 / ARG1）表达。我们提出了追求和白慧穴位的电针可以调节微胶质极化并降低 βPLAQUES在轻度广告小鼠中改善学习和记忆。SN - 2090-5904 UR - https://doi.org/10.1155/2020/8836173 do - 10.1155 / 2020/8836173 jf - 神经塑性pb - hindawi kw - er -