TY -的盟Palasz Ewelina盟——Niewiadomski维克托•AU - Gasiorowska安娜盟——Mietelska-Porowska安娜盟——Niewiadomska Grazyna PY - 2019 DA - 2019/04/03 TI -神经可塑性和神经保护作用的跑步机训练慢性帕金森疾病的小鼠模型SP - 8215017六世- 2019 AB -体能训练授予保护多巴胺神经元的神经毒素产生的震颤麻痹的啮齿动物模型。爱惜身体训练对多巴胺神经元的影响可以被测试,培训期间实施注射慢性MPTP药物治疗,而neurorestorative效应当培训是应用在完成这样的待遇。在这项研究中,开始培训的效果分别注射慢性MPTP药物治疗是专门解决。三组小鼠注射10注射剂量的MPTP药物(12.5毫克/公斤/注射)/ 5周。第一组保持久坐;第二个接受早发性训练,开始1周注射开始MPTP药物治疗前,贯穿治疗5周之后4周;第三组经历了晚发性的培训与前者相同的长度和强度,除了它注射结束后立即MPTP药物治疗。两组担任控制:saline-injected集团保持久坐和saline-injected集团也进行了培训早和晚发性培训组。早和晚发性体能训练了几乎所有nigral和分泌多巴胺能神经元,防止炎症反应,增加了BDNF和GDNF水平类似的程度。从这些结果可以得出结论,早和晚发性培训时间表是均等的神经保护作用和神经保护机制是相似的。 The sparing effect of early onset training may be satisfactorily explained by assuming that the increased level of BDNF and GDNF prevented the degeneration of dopaminergic neurons. To explain a similar number of dopaminergic neurons detected at the end of the early and late-onset training, one should additionally assume that the former training schedule induced neurogenesis. Results of this study support the view that physical activity may be neuroprotective even at a more advanced stage of PD and justify starting physical activity at any point of the disease. SN - 2090-5904 UR - https://doi.org/10.1155/2019/8215017 DO - 10.1155/2019/8215017 JF - Neural Plasticity PB - Hindawi KW - ER -