TY - JOUR AU - Halbertsma, Hinke N. AU - Haak, Koen V. AU - Cornelissen, Frans W. PY - 2019 DA - 2019/09/03SP - 6067871 VL - 2019 AB -视觉系统损伤可导致(部分)视力丧失，作为回应，视觉系统可能会在功能上重组。然而，这种情况发生的时间、程度和条件尚不清楚。因此，需要对具有不同先天和后天条件的个体进行研究，并使用不同的方法来更好地理解这一点。在目前的研究中，我们检查了一个年轻女孩的视觉系统，她在三岁时接受了半球切除术，并因此遭受偏盲。我们通过评估她左半球视觉系统的皮质皮质和视网膜皮质投射来完成。为了检查这些方面，我们基于静息状态(RS)和视网膜检查数据分析了连接场(“神经参考”感受场)的特征。RS数据的评估反映了独立于视觉刺激的大脑活动，特别有趣，因为它不会因患者的非典型视觉感知而产生偏见。我们发现，主要在患者休息时，V1与早期和晚期视区之间的连接域比正常大。这些异常大的连接场可能是功能性重组的标志，也可能是通常被半球间信号掩盖的未掩盖的抑制性反馈信号的标志。 Furthermore, we confirmed our previous finding of abnormal retinocortical or “stimulus-referred” projections in both early and late visual areas. More specifically, we found an enlarged foveal representation and smaller population receptive fields. These differences could also be a sign of functional reorganization or rather a reflection of the interruption visual information that travels, via the remainder of the visual pathway, from the retina to the visual cortex. To conclude, while we do find indications for relatively subtle changes in visual field map properties, we found no evidence of large-scale reorganization—even though the patient could have benefitted from this. Our work suggests that at a later developmental stage, large-scale reorganization of the visual system no longer occurs, while small-scale properties may still change to facilitate adaptive processing and viewing strategies. SN - 2090-5904 UR - https://doi.org/10.1155/2019/6067871 DO - 10.1155/2019/6067871 JF - Neural Plasticity PB - Hindawi KW - ER -