TY - JOUR A2 - Ushiba Junichi AU - Sherwood, Matthew S. AU - Madaris, Aaron T. AU - Mullenger, Casserly R. AU - McKinley，r·安迪PY - 2018 DA - 2018/09/05 TI -重复经颅电刺激诱发量化测量静息脑灌注的变化从动脉自旋标记SP - 5769861六世- 2018 AB -使用经颅电刺激(te)作为一个方法来增强神经活动增加了在过去的十年中,声望a half. The specific application of TES to the left prefrontal cortex has been shown to produce broad cognitive effects; however, the neural mechanisms underlying these effects remain unknown. In this work, we evaluated the effect of repetitive TES on cerebral perfusion. Stimulation was applied to the left prefrontal cortex on three consecutive days, and resting cerebral perfusion was quantified before and after stimulation using arterial spin labeling. Perfusion was found to decrease significantly more in a matched sham stimulation group than in a group receiving active stimulation across many areas of the brain. These changes were found to originate in the locus coeruleus and were broadly distributed in the neocortex. The changes in the neocortex may be a direct result of the stimulation or an indirect result via the changes in the noradrenergic system produced from the altered activity of the locus coeruleus. These findings indicate that anodal left prefrontal stimulation alters the activity of the locus coeruleus, and this altered activity may excite the noradrenergic system producing the broad behavioral effects that have been reported. SN - 2090-5904 UR - https://doi.org/10.1155/2018/5769861 DO - 10.1155/2018/5769861 JF - Neural Plasticity PB - Hindawi KW - ER -