TY - Jour A2 - Kaczmarek，Leszek Au - Wright，John W. Au - Harding，Joseph W. PY - 2009 DA - 2010/02/10 TI - 基质金属蛋白酶对神经可塑性，习惯，联想学习和吸毒成瘾的贡献- 579382 VL - 2009 AB - The premise of this paper is that increased expression of matrix metalloproteinases (MMPs) permits the reconfiguration of synaptic connections (i.e., neural plasticity) by degrading cell adhesion molecules (CAMs) designed to provide stability to those extracellular matrix (ECM) proteins that form scaffolding supporting neurons and glia. It is presumed that while these ECM proteins are weakened, and/or detached, synaptic connections can form resulting in new neural pathways. Tissue inhibitors of metalloproteinases (TIMPs) are designed to deactivate MMPs permitting the reestablishment of CAMs, thus returning the system to a reasonably fixed state. This review considers available findings concerning the roles of MMPs and TIMPs in reorganizing ECM proteins thus facilitating the neural plasticity underlying long-term potentiation (LTP), habituation, and associative learning. We conclude with a consideration of the influence of these phenomena on drug addiction, given that these same processes may be instrumental in the formation of addiction and subsequent relapse. However, our knowledge concerning the precise spatial and temporal relationships among the mechanisms of neural plasticity, habituation, associative learning, and memory consolidation is far from complete and the possibility that these phenomena mediate drug addiction is a new direction of research. SN - 2090-5904 UR - https://doi.org/10.1155/2009/579382 DO - 10.1155/2009/579382 JF - Neural Plasticity PB - Hindawi Publishing Corporation KW - ER -