盟泰斯科巴- A2的还,多米尼克-穆罕默德,Shadi公元盟——刘Hanxing AU - Baldi,萨勒姆盟——陈记者AU - Lu,方非盟- Liu Shumin PY - 2022 DA - 2022/09/17 TI - GJD调节心脏和血管炎症和降低血压高血压大鼠SP - 7345116六世- 2022 AB - Gedan江垭汤(GJD)(含水乙醇提取),中药配方含有六个植物药物(钩藤rhynchophylla进行筛选)。进行筛选。丹参Bunge,葛根(Willd)。Ohwi,杜仲摘要。夏枯草寻常的L。,牛膝bidentata布鲁姆)旨在治疗高血压;然而,潜在的作用机制还不清楚。本研究旨在确定GJD治疗高血压的作用机制在自发性高血压大鼠(月)。男性月被随机分为五组:GJD剂量较低(1.36 g / kg / d),中等(2.72 g / kg / d),和高(5.44 g / kg / d)、卡托普利(13.5毫克/公斤/天),和月组,Wistar-Kyoto大鼠(WKY)作为控制。每个老鼠强饲法一天一次。ALC-NIBP,无创血压的装置,测量收缩压(SBP)、舒张压(菲律宾)血压。 Six weeks following treatment, all rats were anesthetized. The blood samples were obtained from the abdominal aorta and then serum isolated to assess endothelin-1 and angiotensin II, interleukin-1beta, interleukin-6, and TNF-alpha. The left ventricular and thoracic aortas were taken for HE staining, immunohistochemistry, RT-qPCR, and western blot examination. Following GJD therapy, SBP and DBP were significantly lowered, as were serum levels of endothelin-1 and angiotensin II. The thickness of the left ventricular and thoracic aorta walls reduced, as did type I collagen, type III collagen, and alpha-SMA expression in the left ventricular and aortic tissues. The GJD treatment significantly reduced serum levels of the inflammatory markers interleukin-1beta, interleukin-6, and TNF-alpha. Furthermore, interleukin-1 beta, interleukin-6, TNF-alpha, TAK1, and NF- κB / p65水平显著降低左心室和主动脉组织,而IkB-alpha水平显著升高。对所有参数GJD已经存在剂量依赖的相关性影响。总之,GJD已被证实能够降低血压、改善心血管重构,通过调节NF -减少炎症 κB在萎缩。SN - 0962 - 9351你2022/7345116 / 10.1155——https://doi.org/10.1155/2022/7345116——摩根富林明,炎症介质PB - Hindawi KW - ER